Disease - EDK - BIG Data Center

Disease name	Colorectal Cancer
Classfication	Cancer
Related Enzyme(s)
EFO	EFO:0005842
DOID	9256
OMIM	OMIM:114500 OMIM:608812 OMIM:611469 OMIM:612229 OMIM:612230 OMIM:612231 OMIM:612232 OMIM:612589
NCI	-
Definition	Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).

Gene symbol	Species	Enzyme	Editing site(s)	Editing Type	PMID	Description
RHOQ	Human	NA	1	A-to-I	24663214	Among colorectal adenocarcinoma patients, recurrence was more frequently observed in patients with tumors having edited RHOQ transcripts. The RNA editing in RHOQ is asparagin (AAT) to serine (AGT) at residue 136.
BLCAP	Human	ADAR1;ADAR2	12	A-to-I	19908260	BLCAP-editing level is Decrease in bladder cancer, astrocytomas, colorectal cancer.
HNRNPK	Human	APOBEC3B	1	G-to-A	16404425	G-to-A base substitution at position 274 of K protein mRNA that was found in colorectal tumors and surrounding mucosa, but not in individuals that had no colorectal tumor.